Siapa yang tidak tahu akan Sinetron Mahabarata di ANTV, seiring dengan kesuksesan Sinetron dari India dan disadur berdasarkan susastra Mahabharata, maka para pemain / pemeran sinetron ini juga menuai kesuksesan dan memiliki penggemar masing-masing. Dibawah ini adalah daftar pemeran Sinetron Mahabarata.
- Saurabh Raj Jain as Lord Krishna
- Shaheer Sheikh as Arjuna
- Pooja Sharma as Draupadi
- Aham Sharma as Karna
- Arav Chowdhary as Bhishma
- Praneet Bhatt as Shakuni
- Rohit Bharadwaj as Yudhisthira
- Saurav Gurjar as Bhima
- Arpit Ranka as Duryodhana
- Vin Rana as Nakula
- Lavanya Bhardwaj as Sahadeva
- Nissar Khan as Dronacharya
- Pallavi Subhash as Goddess Rukmini
- Atul Mishra as Lord Ved Vyas
- Hemant Choudhary as Kripacharya
- Ratan Rajput as Amba
- Sayantani Ghosh as Satyavati
- Nirbhay Wadhwa as Dushasana
- Vibha Anand as Subhadra
- Shikha Singh as Shikhandini
- Anoop Singh Thakur as King Dhritarashtra
- Riya Deepsi as Queen Gandhari
- Shafaq Naaz as Kunti
- Naveen Jingar as Vidura
- Garima Jain as Dushala
- Sabar Kashyap as Yuyutsu
- Sudesh Berry as King Drupada
- Karan Suchak as Dhrishtadyumna
- Nazea Hasan Sayed as Vrishali
- Ankit Mohan as Ashwatthama
- Sandeep Arora as Vikarna
- Chandani Sharma as Kripi
- Vivana Singh as Goddess Ganga
- Sameer Dharmadhikari as Emperor Shantanu
- Aryamann Seth as Vichitravirya
- Aparna Dixit as Ambika
- Mansi Sharma as Ambalika
- Arun Rana as Pandu
- Nidhi Tiwari as Sukhada
- Suhani Dhanki as Madri
- Ajay Mishra as Sanjaya
- Ali Hassan as Takshak
- Tinu Verma as King Jarasandha
- Tarun Khanna as Balarama
- Vaishnavi Dhanraj as Demoness Hidimbaa
- Ketan Karande as Ghatothkach
- Joy Mathur as Shishupala
- Puneet Issar as Lord Parshurama
- Mohit Raina as Lord Shiva
- Nikhil Arya as Lord Indra
- Kunal Bhatia as Lord Agni
- Gurpreet Singh as Prince Rukmi
- Jayantika Sengupta as Arshi
- Rio Kapadia as King Subala
- Shweta Gautam as Queen Sudarma
- Raj Premi as Demon Kalayavan
- Siddhant Gautam as Ekalavya
- Vidyut Xavier as Karna (Teenage)
- Aayush Shah as Ashwathama (Teenage)
- Rohit Shetty as young Yudhisthira
- Miraj Joshi as young Bhima
- Alam Khan as young Duryodhana
- Soumya Singh as young Arjuna
- Raj Shah as young Dushasana
- Devesh Ahuja as young Nakula
- Rudraksh Jaiswal as young Sahadeva
- Ashnoor Kaur as young Dushala
- Gananay Shukla as young Karna
- Yagya Saxena as young Ashwathama
- Gurbani Thappar as young Malini
